Open conformation chromatin and pluripotency
نویسندگان
چکیده
منابع مشابه
Open conformation chromatin and pluripotency.
Pluripotency, the ability of a cell to give rise to all of the cells of an organism, is a fascinating and mysterious characteristic of embryonic stem (ES) cells. Recent extensive molecular studies of mouse ES cells have revealed the roles played by transcription factor networks and epigenetic processes in the maintenance of ES cell pluripotency (Niwa 2007). However, no direct evidence to connec...
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Pluripotent cells are characterized by infinite self-renewal and unrestricted differentiation potential with far-reaching implications in developmental biology and regenerative medicine. Somatic cells can be reprogrammed to a pluripotent state by ectopic expression of defined transcription factors (TFs) such as Oct4, Klf4, Sox2, and c-Myc, generating induced pluripotent stem cells (iPSCs). This...
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Stem cells of all types are characterized by a stable, heritable state permissive of multiple developmental pathways. The past five years have seen remarkable advances in understanding these heritable states and the ways that they are initiated or terminated. Transcription factors that bind directly to DNA and have sufficiency roles have been most easy to investigate and, perhaps for this reaso...
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The pluripotent state of embryonic stem cells (ESCs) provides a unique perspective on regulatory programs that govern self-renewal and differentiation and somatic cell reprogramming. Here, we review the highly connected protein and transcriptional networks that maintain pluripotency and how they are intertwined with factors that affect chromatin structure and function. The complex interrelation...
متن کاملMapping chromatin conformation
Chromatin conformation capture (3C) and related techniques have become well-established methods to examine which distal DNA sequences are spatially located close to a locus of interest. Hi-C is a new addition to the growing set of 3C-based techniques that has extended the approach to a genome-wide analysis of nuclear chromatin using high-throughput DNA sequencing to generate global interaction ...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2007
ISSN: 0890-9369
DOI: 10.1101/gad.1615707